Abstract: To investigate the practical effectiveness of combined landslide treatment using anti-slide piles and anchor cable frame lattices for loess high-slope landslides, and to address the technical challenges of landslide disaster prevention and control in the transition zone between loess terraces and erosive loess ridge-hill areas in northwest China, this study takes the Hongshangen area at the foot of Gaolan Mountain in Chengguan District as a typical engineering case. This region features complex geological conditions and frequent landslide disasters that severely threaten the safety of proposed construction sites and buildings, necessitating an effective and reasonable comprehensive treatment approach. Based on landslide stability analysis and integrating qualitative and quantitative evaluation results, a combined treatment scheme was proposed, including anti-slide pile retaining, stepped anchor cable frame lattice reinforcement, drainage works, and slope greening. Specifically, anti-slide piles provide key retaining force; stepped anchor cable frame lattices, arranged according to slope height, systematically reinforce the slope; supporting drainage works effectively control surface and groundwater seepage; and slope greening enhances the regional green space ratio and ecological landscape. Engineering practice shows that this combined treatment scheme achieves remarkable effects. It successfully eliminates landslide hazards, fundamentally improves slope stability, and simultaneously optimizes the ecological landscape while increasing the green space ratio. The study demonstrates that the combined treatment technology using anti-slide piles and anchor cable frame lattices can effectively address the landslide risks of high loess slopes. It provides a reasonable and reliable engineering pathway for landslide treatment in similar loess transition zones in northwest China, achieving multiple benefits including disaster prevention and mitigation, safeguarding economic and social development, and enhancing project quality.