Abstract: Gansu region is situated at the intersection of multiple active tectonic fault zones, characterized by frequent seismic activity and a history of strong earthquakes. Studying the spectral characteristics of the response spectrum in this region is of great significance for engineering seismic design and disaster risk assessment. This paper investigates the response spectrum characteristics of the Minxian Ms6.7 and Wenchuan Ms8.0 earthquakes based on strong-motion records, and compares them with design response spectra. The results indicate that: 1） The soil layer （medium） exhibits a pronounced amplification effect, with acceleration response spectral values increasing as the epicentral distance grows; 2） For the Minxian earthquake, the average spectra in regions with basic design accelerations of 0.15g and 0.2g are consistent with design spectra, but their peak values exceed the plateau values of design spectra, significantly impacting the safety performance of engineering structures; 3） In the Wenchuan earthquake, the average spectra for regions with basic design accelerations of 0.15g and 0.2g were underestimated in long-period components. The predominant period of the 0.2g average spectrum exceeds the characteristic period of the corresponding design spectrum, suggesting the need to appropriately increase spectral values in long-period ranges and extend characteristic periods. For strong seismic motions, the design spectral values specified in current codes should be partially adjusted according to actual conditions.