Abstract: The wheel damage seriously affects the service life of the wheel set of the subway train.In order to analyze the influence of the train with different passenger flow on the wheel damage of the subway train, taking the subway B-type vehicle as the research object, the vehicle-track system dynamics model is established and the global contact parameters are calculated.The Archard wear model is used to simulate and analyze the wheel wear characteristics, the Kik-Piotrowski model is used to simulate the wheel-rail contact, and the UM RCF of Rails module is used to analyze the change rule of rolling contact fatigue under different passenger flow loads.The results show that the wheel wear and rolling contact fatigue are affected by the passenger flow load.The greater the passenger flow load, the greater the wear and rolling contact fatigue value.Under the C curve, the influence of passenger flow load on the wear rate of the flange and tread of the 1,4-position wheel is greater than that of the 2,3-position wheel; the wheel wear rate on the straight line shows a trend from slow to fast and then to slow due to the influence of passenger flow load.The change of passenger flow load will not change the fatigue damage area of the wheel and the damage range of the straight wheel is larger than that of the curved wheel.This conclusion provides a theoretical basis for the later maintenance of subway train wheels.