Abstract: Taking the selected gazelle enterprises in Fujian Province as the research object, the study found that the two centers around Gulou District and Xiamen islandshowes a spatial pattern of "North-South nuclear linkage development and coastal distribution as corridor ".Based on the geographical detector model, it is found that the main factors affecting the spatial differentiation of gazelle enterprises are innovation ability and regional innovation environment.In addition, factor agglomeration and location characteristics also affect the spatial distribution of Gazelle enterprises.Interactive detection analysis shows that spatial differentiation is not caused by a single factor, but by the interaction and coupling of multiple factors.Finally, the paper puts forward some policy suggestions from the perspectives of building a professional R＆D team, so as to improve the allocation efficiency of human capital factors, and enhance the quality of patents and promoting the construction of accelerators.